Balancing purification and ultrastructure of naturally derived bone blocks for bone regeneration

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dc.contributor.authorBarbeck, Mike
dc.contributor.authorJung, Ole
dc.contributor.authorXiong, Xin
dc.contributor.authorKrastev, Rumen
dc.contributor.authorKorzinskas, Tadas
dc.contributor.authorNajman, Stevo
dc.contributor.authorRadenković, Milena
dc.contributor.authorWegner, Nils
dc.contributor.authorKnyazeva, Marina
dc.contributor.authorWalther, Frank
dc.date.accessioned2020-02-04T12:19:53Z
dc.date.available2020-02-04T12:19:53Z
dc.date.issued2019-10-02
dc.description.abstractThe present publication reports the purification effort of two natural bone blocks, that is, an allogeneic bone block (maxgraft®, botiss biomaterials GmbH, Zossen, Germany) and a xenogeneic block (SMARTBONE®, IBI S.A., Mezzovico-Vira, Switzerland) in addition to previously published results based on histology. Furthermore, specialized scanning electron microscopy (SEM) and in vitro analyses (XTT, BrdU, LDH) for testing of the cytocompatibility based on ISO 10993-5/-12 have been conducted. The microscopic analyses showed that both bone blocks possess a trabecular structure with a lamellar subarrangement. In the case of the xenogeneic bone block, only minor remnants of collagenous structures were found, while in contrast high amounts of collagen were found associated with the allogeneic bone matrix. Furthermore, only island-like remnants of the polymer coating in case of the xenogeneic bone substitute seemed to be detectable. Finally, no remaining cells or cellular remnants were found in both bone blocks. The in vitro analyses showed that both bone blocks are biocompatible. Altogether, the purification level of both bone blocks seems to be favorable for bone tissue regeneration without the risk for inflammatory responses or graft rejection. Moreover, the analysis of the maxgraft® bone block showed that the underlying purification process allows for preserving not only the calcified bone matrix but also high amounts of the intertrabecular collagen matrix.en
dc.identifier.urihttp://hdl.handle.net/2003/38546
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-20465
dc.language.isoenen
dc.relation.ispartofseriesMaterials;2019, 12(19), 3234
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectBone blocken
dc.subjectAllogeneicen
dc.subjectXenogeneicen
dc.subjectPurificationen
dc.subjectBone regenerationen
dc.subjectDentistryen
dc.subject.ddc660
dc.subject.rswkKnochenspande
dc.subject.rswkAllogenes Transplantatde
dc.subject.rswkHeterotransplantationde
dc.subject.rswkProduktaufarbeitungde
dc.subject.rswkKnochenbildungde
dc.subject.rswkZahnmedizinde
dc.titleBalancing purification and ultrastructure of naturally derived bone blocks for bone regenerationen
dc.title.alternativereport of the purification effort of two bone blocksen
dc.typeTextde
dc.type.publicationtypearticlede
dcterms.accessRightsopen access
eldorado.secondarypublicationtruede
eldorado.secondarypublication.primarycitationMaterials. 2019, 12(19), 3234de
eldorado.secondarypublication.primaryidentifierhttps://doi.org/10.3390/ma12193234de

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