A Self-Designing Rule for Clinical Trials with Arbitrary Response Variables
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Date
2000
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Publisher
Universitätsbibliothek Dortmund
Abstract
For testing one{sided but also two{sided hypotheses concerning several treatment arms in group sequentially performed clinical trials with arbitrary outcome variables, a general learning method is considered that allows for a complete self-designing of the study. All information available prior to a stage is used for estimating the sample size and the weight for the next step. In 'using up' the variance, the test statistic is built in a bounded finite but random number of stages to