Complexity-reduction by first-order approximation of non-linear kinetics

dc.contributor.authorBecka, Michaelde
dc.date.accessioned2004-12-06T18:38:30Z
dc.date.available2004-12-06T18:38:30Z
dc.date.issued1998de
dc.description.abstractEcological, toxicological, and pharmacological research is often concerned with the answer to the question of how a substance is processed within a biological system. The exact knowledge of the corresponding kinetic pattern forms the basis for a useful answer. In order to identify non-linear kinetics, a first-order approximation method is proposed for complexity-reduction. A simulation study is presented to investigate the error of the approximation in case of a simple Michaelis-Menten kinetic process. The proposed method shows to give useful results which allow to characterize the underlying kinetic pattern. Furthermore it could be shown that in simulating kinetic processes the applied numerical methods may perform with considerable numerical instabilities.en
dc.format.extent2714317 bytes
dc.format.extent477636 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypeapplication/postscript
dc.identifier.urihttp://hdl.handle.net/2003/4851
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-15017
dc.language.isoende
dc.publisherUniversitätsbibliothek Dortmundde
dc.subjectcompartmental modelen
dc.subjectdynamic processen
dc.subjectfirst-order approximationen
dc.subjectMichaelis-Menten kineticen
dc.subjectnon-linear kineticen
dc.subjectnumerical integrationen
dc.subject.ddc310de
dc.titleComplexity-reduction by first-order approximation of non-linear kineticsen
dc.typeTextde
dc.type.publicationtypereporten
dcterms.accessRightsopen access

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