Authors: Berman, A. E.
Chubukina, A. N.
Kozlova, N. I.
Morozevich, G. E.
Shtil, A. A.
Title: Expression of Integrins, Anchorage Dependent Apoptosis and Invasiveness of Multidrug Resistant Human Breast Carcinoma Cells
Language (ISO): en
Abstract: The aim of the study was to investigate the role of integrins in anchorage dependent apoptosis (anoikis) and in vitro invasion of human breast cancer cell line MCF-7 and its multidrug resistant subline MCF-7Dox. Acquisition of MDR was associated with markedly decreased expression of collagen specific a2ß1 and avß3 integrins, laminin specific a3ß1 and a6ß1 receptors and dramatic up-regulation of fibronectin specific a5ß1 integrin. The MDR subline was substantially more resistant to anoikis than their wild type counterparts. Furthermore, MCF-7Dox cells secreted MMP-9 collagenase and invaded Matrigel. We demonstrate for the first time that stimulation of ß1 integrin signaling strongly sensitizes MCF-7 cells to anoikis.
Subject Headings: anoikis
integrins
multidrug resistance
tumor invasion
URI: http://hdl.handle.net/2003/25638
http://dx.doi.org/10.17877/DE290R-337
Issue Date: 2004-10-11
Appears in Collections:Original Articles

Files in This Item:
File Description SizeFormat 
Berman09-04proofrev.pdfDNB568.36 kBAdobe PDFView/Open


This item is protected by original copyright



All resources in the repository are protected by copyright.