Authors: | Berman, A. E. Chubukina, A. N. Kozlova, N. I. Morozevich, G. E. Shtil, A. A. |
Title: | Expression of Integrins, Anchorage Dependent Apoptosis and Invasiveness of Multidrug Resistant Human Breast Carcinoma Cells |
Language (ISO): | en |
Abstract: | The aim of the study was to investigate the role of integrins in anchorage dependent apoptosis (anoikis) and in vitro invasion of human breast cancer cell line MCF-7 and its multidrug resistant subline MCF-7Dox. Acquisition of MDR was associated with markedly decreased expression of collagen specific a2ß1 and avß3 integrins, laminin specific a3ß1 and a6ß1 receptors and dramatic up-regulation of fibronectin specific a5ß1 integrin. The MDR subline was substantially more resistant to anoikis than their wild type counterparts. Furthermore, MCF-7Dox cells secreted MMP-9 collagenase and invaded Matrigel. We demonstrate for the first time that stimulation of ß1 integrin signaling strongly sensitizes MCF-7 cells to anoikis. |
Subject Headings: | anoikis integrins multidrug resistance tumor invasion |
URI: | http://hdl.handle.net/2003/25638 http://dx.doi.org/10.17877/DE290R-337 |
Issue Date: | 2004-10-11 |
Appears in Collections: | Original Articles |
Files in This Item:
File | Description | Size | Format | |
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Berman09-04proofrev.pdf | DNB | 568.36 kB | Adobe PDF | View/Open |
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