Authors: Muhammad, Aminu
Sirat, Hasnah Mohd
Title: COX-2 inhibitors from stem bark of Bauhinia rufescens Lam. (Fabaceae)
Language (ISO): en
Abstract: Chemical investigation of the stem bark of Bauhinia rufescens resulted in the isolation of a new cyanoglucoside and menisdaurin from methanol extract and oxepin from petroleum ether extract. The isolated compounds were tested for their anti-inflammatory potentials based on the cyclooxygenase-2 enzyme (COX-2) model. Cyanoglucoside exhibited the highest activity among the compounds with an inhibition activity of 49.34 % at 100 μM (IC50 0.46 μM) compared to the positive control, indomethacin (79.20 %, IC50 0.24 μM).
Subject Headings: COX-2
Bauhinia rufescens
Issue Date: 2013-09-13
Appears in Collections:Original Articles

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