Authors: | Muhammad, Aminu Sirat, Hasnah Mohd |
Title: | COX-2 inhibitors from stem bark of Bauhinia rufescens Lam. (Fabaceae) |
Language (ISO): | en |
Abstract: | Chemical investigation of the stem bark of Bauhinia rufescens resulted in the isolation of a new cyanoglucoside and menisdaurin from methanol extract and oxepin from petroleum ether extract. The isolated compounds were tested for their anti-inflammatory potentials based on the cyclooxygenase-2 enzyme (COX-2) model. Cyanoglucoside exhibited the highest activity among the compounds with an inhibition activity of 49.34 % at 100 μM (IC50 0.46 μM) compared to the positive control, indomethacin (79.20 %, IC50 0.24 μM). |
Subject Headings: | COX-2 Bauhinia rufescens phytochemicals |
URI: | http://hdl.handle.net/2003/32961 http://dx.doi.org/10.17877/DE290R-7476 |
Issue Date: | 2013-09-13 |
Appears in Collections: | Original Articles |
Files in This Item:
File | Description | Size | Format | |
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Sirat_13092013_proof.pdf | DNB | 197.08 kB | Adobe PDF | View/Open |
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