Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Konstantinou, Maria | - |
dc.contributor.author | Biedermann, Stefanie | - |
dc.contributor.author | Kimber, Alan | - |
dc.date.accessioned | 2016-07-25T11:23:48Z | - |
dc.date.available | 2016-07-25T11:23:48Z | - |
dc.date.issued | 2016 | - |
dc.identifier.uri | http://hdl.handle.net/2003/35156 | - |
dc.identifier.uri | http://dx.doi.org/10.17877/DE290R-17203 | - |
dc.description.abstract | The exponential-based proportional hazards model is often assumed in time- to-event experiments but may only approximately hold. We consider deviations in different neighbourhoods of this model that include other widely used paramet- ric proportional hazards models and we further assume that the data are subject to censoring. Minimax designs are then found explicitly based on criteria corre- sponding to classical c- and D-optimality. We provide analytical characterisations of optimal designs which, unlike optimal designs for related problems in the litera- ture, have finite support and thus avoid the issues of implementing a density-based design in practice. Finally, our designs are compared with the balanced design that is traditionally used in practice, and recommendations for practitioners are given. | en |
dc.language.iso | en | de |
dc.relation.ispartofseries | Discussion Paper / SFB823;38, 2016 | en |
dc.subject | proportional hazards models | en |
dc.subject | Type-I censoring | en |
dc.subject | c-optimality | en |
dc.subject | D-optimality | en |
dc.subject | minimax optimal designs | en |
dc.subject.ddc | 310 | - |
dc.subject.ddc | 330 | - |
dc.subject.ddc | 620 | - |
dc.title | Model robust designs for survival trials | en |
dc.type | Text | de |
dc.type.publicationtype | workingPaper | de |
dcterms.accessRights | open access | - |
Appears in Collections: | Sonderforschungsbereich (SFB) 823 |
Files in This Item:
File | Description | Size | Format | |
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DP_3816_SFB823_Konstantinou_Biedermann_Kimber.pdf | DNB | 349.86 kB | Adobe PDF | View/Open |
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