Authors: | Konstantinou, Maria Biedermann, Stefanie Kimber, Alan |
Title: | Model robust designs for survival trials |
Language (ISO): | en |
Abstract: | The exponential-based proportional hazards model is often assumed in time- to-event experiments but may only approximately hold. We consider deviations in different neighbourhoods of this model that include other widely used paramet- ric proportional hazards models and we further assume that the data are subject to censoring. Minimax designs are then found explicitly based on criteria corre- sponding to classical c- and D-optimality. We provide analytical characterisations of optimal designs which, unlike optimal designs for related problems in the litera- ture, have finite support and thus avoid the issues of implementing a density-based design in practice. Finally, our designs are compared with the balanced design that is traditionally used in practice, and recommendations for practitioners are given. |
Subject Headings: | proportional hazards models Type-I censoring c-optimality D-optimality minimax optimal designs |
URI: | http://hdl.handle.net/2003/35156 http://dx.doi.org/10.17877/DE290R-17203 |
Issue Date: | 2016 |
Appears in Collections: | Sonderforschungsbereich (SFB) 823 |
Files in This Item:
File | Description | Size | Format | |
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DP_3816_SFB823_Konstantinou_Biedermann_Kimber.pdf | DNB | 349.86 kB | Adobe PDF | View/Open |
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