Authors: Wysoczanska, Kamila
Do, Hoang Tam
Sadowski, Gabriele
Macedo, Eugénia A.
Held, Christoph
Title: Partitioning of water-soluble vitamins in biodegradable aqueous two-phase systems
Other Titles: electrolyte perturbed-chain statistical associating fluid theory predictions and experimental validation
Language (ISO): en
Abstract: Partition coefficients (K) of vitamins (riboflavin, nicotinic acid, nicotinamide, folic acid, cyanocobalamin) in aqueous two-phase systems (ATPS) composed by polyethylene glycol (PEG 4000, PEG 6000) and organic salt (sodium citrate and sodium tartrate) at T = 298.15 K and p = 1 bar have been studied. Data on liquid–liquid equilibria of the ATPS considered in this study have been taken from the literature (PEG-Na3Citrate) or measured in this work (PEG-Na2Tartrate) for PEG 4000 and PEG 6000 at T = 298.15 K and p = 1 bar. The experimental K values were validated by electrolyte perturbed-chain-statistical associating fluid theory predictions. The neutral cyanocobalamin has the highest K values among all studied vitamins at any ATPS studied in this work. This finding contrasted with expectations based on literature data which let assume that charged species have typically the highest K values in the considered ATPS. Thus, besides the typically strong charge–charge interactions especially specific forces (e.g., hydrogen bonding) explains the strong PEG-cyanocobalamin interaction resulting in the high K values.
Subject Headings: Citrate
Partition coefficient
Weak electrolytes
Issue Date: 2020-07-14
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Appears in Collections:Lehrstuhl Thermodynamik

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