Authors: Winker, Matteo
Stössel, Sandra
Neu, Marie Astrid
Lehmann, Nadine
El Malki, Khalifa
Paret, Claudia
Joisten, Niklas
Bloch, Wilhelm
Zimmer, Philipp
Faber, Jörg
Title: Exercise reduces systemic immune inflammation index (SII) in childhood cancer patients
Language (ISO): en
Abstract: While exercise and physical activity have been suggested to reduce mortality and symptoms in cancer, knowledge on these associations in patients with childhood cancer (CCPs) is sparse. Anti-inflammatory properties of exercise might mediate these beneficial effects. We investigated the influence of exercise on the inflammation markers neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic-immune-inflammation index (SII) and associations to patient-reported-outcomes in CCPs in a randomized-controlled trial. Results show associations between inflammation markers and patient-reported outcomes. Compared to the control group, SII was significantly reduced following exercise (p=0.036). Anti-inflammatory effects of exercise are also present in CCPs and may underlie exercise-induced benefits on symptoms. Clinical Trial Registration Number: NCT02612025
Subject Headings: Tumor entities
Cellular inflammation
Pediatric oncology
Resistance training
Endurance training
Subject Headings (RSWK): Kind
Issue Date: 2021-12-03
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Appears in Collections:Institut für Sport und Sportwissenschaft

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