Authors: Winker, Matteo
Stössel, Sandra
Neu, Marie Astrid
Lehmann, Nadine
El Malki, Khalifa
Paret, Claudia
Joisten, Niklas
Bloch, Wilhelm
Zimmer, Philipp
Faber, Jörg
Title: Exercise reduces systemic immune inflammation index (SII) in childhood cancer patients
Language (ISO): en
Abstract: While exercise and physical activity have been suggested to reduce mortality and symptoms in cancer, knowledge on these associations in patients with childhood cancer (CCPs) is sparse. Anti-inflammatory properties of exercise might mediate these beneficial effects. We investigated the influence of exercise on the inflammation markers neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic-immune-inflammation index (SII) and associations to patient-reported-outcomes in CCPs in a randomized-controlled trial. Results show associations between inflammation markers and patient-reported outcomes. Compared to the control group, SII was significantly reduced following exercise (p=0.036). Anti-inflammatory effects of exercise are also present in CCPs and may underlie exercise-induced benefits on symptoms. Clinical Trial Registration Number: NCT02612025
Subject Headings: Tumor entities
Cellular inflammation
Pediatric oncology
Resistance training
Endurance training
Subject Headings (RSWK): Kind
Onkologie
Sport
URI: http://hdl.handle.net/2003/40900
http://dx.doi.org/10.17877/DE290R-22756
Issue Date: 2021-12-03
Rights link: http://creativecommons.org/licenses/by/4.0/
http://creativecommons.org/licenses/by/4.0/
Appears in Collections:Institut für Sport und Sportwissenschaft

Files in This Item:
File Description SizeFormat 
Winker2022_Article_ExerciseReducesSystemicImmuneI.pdf471.18 kBAdobe PDFView/Open


This item is protected by original copyright



This item is licensed under a Creative Commons License Creative Commons