Authors: | Winker, Matteo Stössel, Sandra Neu, Marie Astrid Lehmann, Nadine El Malki, Khalifa Paret, Claudia Joisten, Niklas Bloch, Wilhelm Zimmer, Philipp Faber, Jörg |
Title: | Exercise reduces systemic immune inflammation index (SII) in childhood cancer patients |
Language (ISO): | en |
Abstract: | While exercise and physical activity have been suggested to reduce mortality and symptoms in cancer, knowledge on these associations in patients with childhood cancer (CCPs) is sparse. Anti-inflammatory properties of exercise might mediate these beneficial effects. We investigated the influence of exercise on the inflammation markers neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic-immune-inflammation index (SII) and associations to patient-reported-outcomes in CCPs in a randomized-controlled trial. Results show associations between inflammation markers and patient-reported outcomes. Compared to the control group, SII was significantly reduced following exercise (p=0.036). Anti-inflammatory effects of exercise are also present in CCPs and may underlie exercise-induced benefits on symptoms. Clinical Trial Registration Number: NCT02612025 |
Subject Headings: | Tumor entities Cellular inflammation Pediatric oncology Resistance training Endurance training |
Subject Headings (RSWK): | Kind Onkologie Sport |
URI: | http://hdl.handle.net/2003/40900 http://dx.doi.org/10.17877/DE290R-22756 |
Issue Date: | 2021-12-03 |
Rights link: | http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/ |
Appears in Collections: | Institut für Sport und Sportwissenschaft |
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File | Description | Size | Format | |
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Winker2022_Article_ExerciseReducesSystemicImmuneI.pdf | 471.18 kB | Adobe PDF | View/Open |
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