Authors: | Justen, Anna Kurth, Christopher Schaldach, Gerhard Thommes, Markus |
Title: | Preparation of micron and submicron particles via spray drying and electrostatic precipitation |
Language (ISO): | en |
Abstract: | Small particles are of great interest in a variety of applications. Spray drying is a common technique for particle synthesis, but it is limited with respect to sizes below 10 μm. Therefore, a new laboratory-scale spray dryer was designed to address this issue. A novel aerosol generator consisting of a piezo crystal in a swirl chamber was designed to obtain droplets in the low micrometer range. After drying and cooling, particles were deposited in a molten carrier, using melt electrostatic precipitation. The median particle size of three pharmaceutical drug substances was 2 μm. The size distribution was particularly narrow, with span values of about 1.1. Spray drying is a sufficient technique to produce small drug particles below 5 μm with ultrasonic atomization at high frequencies. Electrostatic precipitation in a molten carrier is a suitable method to capture these particles. |
Subject Headings: | Electrostatic precipitation Micronized particles Spray drying Ultrasonic atomization |
Subject Headings (RSWK): | Elektroentstaubung Teilchengröße Zerstäubungstrocknung Zerstäubung |
URI: | http://hdl.handle.net/2003/42160 http://dx.doi.org/10.17877/DE290R-23993 |
Issue Date: | 2022-11-10 |
Rights link: | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
Appears in Collections: | Lehrstuhl Feststoffverfahrenstechnik |
Files in This Item:
File | Description | Size | Format | |
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Chem Eng Technol - 2022 - Justen - Preparation of Micron and Submicron Particles via Spray Drying and Electrostatic.pdf | DNB | 799.19 kB | Adobe PDF | View/Open |
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