Authors: Vardeman, Stephen B.
Wang, Lily
Wendelberger, Joanne R.
Title: Calibration, Error Analysis, and Ongoing Measurement Process Monitoring for Mass Spectrometry
Language (ISO): en
Abstract: We consider problems of quantifying and monitoring accuracy and precision of measurement in mass spectrometry, particularly in contexts where there is unavoidable day-to-day/period-to-period changes in instrument sensitivity. First we consider the issue of estimating instrument sensitivity based on data from a typical calibration study. Simple method-of-moments methods, likelihood-based methods, and Bayes methods based on the one-way random effects model are illustrated. Then we consider subsequently assessing the precision of an estimate of a mole fraction of a gas of interest in an unknown. Finally, we turn to the problem of ongoing measurement process monitoring and illustrate appropriate set-up of Shewhart control charts in this application.
URI: http://hdl.handle.net/2003/5000
http://dx.doi.org/10.17877/DE290R-15051
Issue Date: 2003
Publisher: Universitätsbibliothek Dortmund
Appears in Collections:Sonderforschungsbereich (SFB) 475

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