Effects of symbiotic and vitamin E supplementation on blood pressure, nitric oxide and inflammatory factors in non-alcoholic fatty liver disease

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dc.contributor.authorEkhlasi, Golnaz
dc.contributor.authorZarrati, Mitra
dc.contributor.authorAgah, Shahram
dc.contributor.authorHosseini, Agha Fatemah
dc.contributor.authorHosseini, Sharieh
dc.contributor.authorShidfar, Shahrzad
dc.contributor.authorSoltani Aarbshahi, Seyed Soroush
dc.contributor.authorRazmpoosh, Elham
dc.contributor.authorShidfar, Farzad
dc.date.accessioned2017-08-28T12:54:45Z
dc.date.available2017-08-28T12:54:45Z
dc.date.issued2017-03-20
dc.description.abstractNon-alcoholic fatty liver disease (NAFLD) has been suggested to be well correlated with altered blood pressure. This study was conducted to determine the effects of symbiotic and vitamin E supplementation on blood pressure and inflammatory indices of patients with NAFLD. This randomized, double-blind, placebo-controlled trial was performed among 60 NAFLD patients aged 25 to 64 years old. Participants were randomly divided into four groups to receive a 400 IU alpha-tocopherol and 2 × 108 CFU/g symbiotic supplement for 8 weeks. The anthropometric parameters, systolic blood pressure (SBP) and diastolic blood pressure (DBP), serum malondialdehyde (MDA), nitric oxide (NO) and tumor necrosis factor α (TNFα) were assessed at baseline and after 8 weeks of intervention. After 8 weeks of intervention, combined symbiotic and alpha-tocopherol, symbiotic and alpha-tocopherol lone administration, compared with the placebo, resulted in significant decreases in SBP (-17.07±2.1, -16.07±3.56, -1.73±2.25 and -1.55±3.01 mmHg, P=0.01), serum MDA (-1.19±0.5, -0.12±0.65, 0.14 ± 0.64 and 0.16±0.34 nmol/mL, P<0.001), serum TNFα (-15.62±13.93, -9.24±7.12, -11.44 ± 15.47 and 3.01±1.71 pg/ml, P<0.001) concentrations. A significant decrease in serum AST (-11.36±4.52, -7.43±8.58, -5.93±6.61 and 2.5±5.75 μmol/L, P <0.001), ALT (-12.79±3.65, -3.66±6.81, -6.54±7.66 and 4.16±3.43 μmol/L, P <0.001) and ALP (-26.8±11.1, -4.56±9.22, -14.48±12.22 and 5.19±2.64 μmol/L, P <0.001) was seen. Variations in DBP and serum NO concentration were not significant. Alpha-tocopherol and symbiotic supplementation among patients with NAFLD resulted in decreased SBP, serum MDA, TNFα levels and enzymes liver; however, they did not affect DBP and serum NO concentration.de
dc.identifier.citationEXCLI Journal 2017;16:278-290de
dc.identifier.issn1611-2156
dc.identifier.urihttp://hdl.handle.net/2003/36075
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-18091
dc.language.isoen
dc.relation.ispartofseriesEXCLI Journal;Vol. 16 2017
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectSymbioticen
dc.subjectAlpha-tocopherolen
dc.subjectBlood pressureen
dc.subjectNitric oxideen
dc.subjectNAFLDen
dc.subject.ddc610
dc.titleEffects of symbiotic and vitamin E supplementation on blood pressure, nitric oxide and inflammatory factors in non-alcoholic fatty liver diseaseen
dc.typeText
dc.type.publicationtypearticle
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1

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