Differential pattern of brain functional connectome in obsessive-compulsive disorder versus healthy controls

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dc.contributor.authorYazdi-Ravandi, Saeid
dc.contributor.authorAkhavanpour, Hassan
dc.contributor.authorShamsaei, Farshid
dc.contributor.authorMatinnia, Nasrin
dc.contributor.authorAhmadpanah, Mohammad
dc.contributor.authorGhaleiha, Ali
dc.contributor.authorKhosrowabadi, Reza
dc.date.accessioned2019-04-02T12:02:56Z
dc.date.available2019-04-02T12:02:56Z
dc.date.issued2018-11-08
dc.description.abstractResearchers believe that recognition of functional impairment in some of brain networks such as frontal-parietal, default mode network (DMN), anterior medial prefrontal cortex (MPFC) and striatal structures could be a beneficial biomarker for diagnosis of obsessive-compulsive disorder (OCD). Although it is well recognized brain functional connectome in OCD patients shows changes, debate still remains on characteristics of the changes. In this regard, little has been done so far to statistically assess the altered pattern using whole brain electroencephalography. In this study, resting state EEG data of 39 outpatients with OCD and 19 healthy controls (HC) were recorded. After, brain functional network was estimated from the cleaned EEG data using the weighted phase lag index algorithm. Output matrices of OCD group and HCs were then statistically compared to represent meaningful differences. Significant differences in functional connectivity pattern were demonstrated in several regions. As expected the most significant changes were observed in frontal cortex, more significant in frontal-temporal connections (between F3 and F7, and T5 regions). These results in OCD patients are consistent with previous studies and confirm the role of frontal and temporal brain regions in OCD.en
dc.identifier.issn1611-2156
dc.identifier.urihttp://hdl.handle.net/2003/37977
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-19962
dc.language.isoen
dc.relation.ispartofseriesEXCLI Journal;Vol. 17 2018
dc.subjectElectroencephalography (EEG)en
dc.subjectObsessive-compulsive disorder (OCD)en
dc.subjectFunctional connectivity (FC)en
dc.subjectWeighted phase lag index (WPLI)en
dc.subject.ddc610
dc.titleDifferential pattern of brain functional connectome in obsessive-compulsive disorder versus healthy controlsen
dc.typeText
dc.type.publicationtypearticle
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1
eldorado.secondarypublicationtrue

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