Octyl gallate induces hepatic steatosis in HepG2 cells through the regulation of SREBP-1c and PPAR-γ gene expression

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dc.contributor.authorLima, Kelly Goulart
dc.contributor.authorSchneider Levorse, Vitor Giancarlo
dc.contributor.authorRosa Garcia, Maria Claudia
dc.contributor.authorde Souza Basso, Bruno
dc.contributor.authorPasqualotto Costa, Bruna
dc.contributor.authorAntunes, Géssica Luana
dc.contributor.authorLuft, Carolina
dc.contributor.authorViegas Haute, Gabriela
dc.contributor.authorLeal Xavier, Léder
dc.contributor.authorDonadio, Márcio Vinícius Fagundes
dc.contributor.authorRodrigues de Oliveira, Jarbas
dc.date.accessioned2020-12-07T09:33:04Z
dc.date.available2020-12-07T09:33:04Z
dc.date.issued2020-07-06
dc.description.abstractOctyl gallate (OG) is an antioxidant commonly used in food, although there is no definition of its acceptable daily intake. There are reports in vitro and in vivo showing that food additives and drugs can alter lipid metabolism. Lipid droplet accumulation in hepatic cells is one of the main findings in the unregulated lipid metabolism and is strongly related to the development of nonalcoholic fatty liver disease (NAFLD). In this study, we investigated the effects of OG on lipid metabolism in the hepatocellular carcinoma cell line (HepG2). The results have shown, for the first time, that treatment with OG increased the overall amount of lipids, the triglyceride concentration, the lipid droplet area, and SREBP-1c and PPAR-γ gene expression. Taken together, the findings indicate that OG induces lipid droplet accumulation in HepG2 cells through the regulation of SREBP-1c and PPAR-γ gene expression without involving mTOR/S6K1 and may contribute to NAFLD when used as a food additive.en
dc.identifier.citationhttps://www.excli.de/index.php/excli/article/view/2214de
dc.identifier.issn1611-2156
dc.identifier.urihttp://hdl.handle.net/2003/39847
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-21738
dc.language.isoen
dc.publisherIfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmunden
dc.relation.ispartofseriesEXCLI Journal;Vol. 19 2020
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectHepatic steatosisen
dc.subjectOctyl gallateen
dc.subjectHepG2 cellsen
dc.subjectLipid dropleten
dc.subjectSREBP-1cen
dc.subjectPPAR-γen
dc.subject.ddc610
dc.titleOctyl gallate induces hepatic steatosis in HepG2 cells through the regulation of SREBP-1c and PPAR-γ gene expressionen
dc.typeText
dc.type.publicationtypearticle
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1
eldorado.secondarypublicationtrue

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