MafB silencing in macrophages does not influence the initiation and growth of lung cancer induced by urethane

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dc.contributor.authorNemoto, Takako
dc.contributor.authorShibata, Yoko
dc.contributor.authorInoue, Sumito
dc.contributor.authorIgarashi, Akira
dc.contributor.authorTokairin, Yoshikane
dc.contributor.authorYamauchi, Keiko
dc.contributor.authorKimura, Tomomi
dc.contributor.authorSato, Masamichi
dc.contributor.authorSato, Kento
dc.contributor.authorNakano, Hiroshi
dc.contributor.authorAbe, Shuichi
dc.contributor.authorNishiwaki, Michiko
dc.contributor.authorKobayashi, Maki
dc.contributor.authorYang, Sujeong
dc.contributor.authorMinegishi, Yukihiro
dc.contributor.authorFuruyama, Kodai
dc.contributor.authorMachida, Hiroyoshi
dc.contributor.authorKubota, Isao
dc.date.accessioned2017-11-22T12:46:59Z
dc.date.available2017-11-22T12:46:59Z
dc.date.issued2017-06-20
dc.description.abstractAn increased number of tumor-associated macrophages (TAMs) that exhibit the M2 macrophage phenotype is related to poorer prognosis in cancer patients. MafB is a transcription factor regulating the differentiation of macrophages. However, involvement of MafB for the development of TAMs is unknown. This study was designed to investigate the role of MafB in a murine urethane-induced lung cancer model. Urethane was injected intraperitoneally into wild-type and dominant-negative MafB transgenic mice. Twenty-four weeks later, mice were sacrificed and their lungs removed for pathological analysis. The numbers and mean areas of lung cancer were evaluated. In addition, the numbers of Mac-3-positive macrophages were evaluated in each tumor. The numbers and mean areas of lung cancer induced by urethane administration were not significantly different between wild-type and dominant-negative MafB transgenic mice. The numbers of TAMs in lung cancer tissue were not significantly different between the two groups. MafB silencing using dominant-negative MafB did not influence the initiation and growth of lung cancer in mice exposed to urethane. These data suggest that MafB may not be related to the development of TAMs.en
dc.identifier.issn1611-2156
dc.identifier.urihttp://hdl.handle.net/2003/36191
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-18207
dc.language.isoen
dc.relation.ispartofseriesEXCLI Journal;Vol. 16 2017
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectMafBen
dc.subjectlung canceren
dc.subjecturethaneen
dc.subjecttumor-associated macrophagesen
dc.subjectgene targeted mouseen
dc.subject.ddc610
dc.titleMafB silencing in macrophages does not influence the initiation and growth of lung cancer induced by urethaneen
dc.typeText
dc.type.publicationtypearticle
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1
eldorado.secondarypublicationtrue

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