Schisandrae Fructus ethanol extract ameliorates inflammatory responses and articular cartilage damage in monosodium iodoacetate-induced osteoarthritis in rats

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dc.contributor.authorJeong, Jin-Woo
dc.contributor.authorKim, Jongsik
dc.contributor.authorChoi, Eun Ok
dc.contributor.authorKwon, Da Hye
dc.contributor.authorKong, Gyu Min
dc.contributor.authorChoi, Il-Whan
dc.contributor.authorKim, Bum Hoi
dc.contributor.authorKim, Gi-Young
dc.contributor.authorLee, Ki Won
dc.contributor.authorKim, Ki Young
dc.contributor.authorKim, Sung Goo
dc.contributor.authorChoi, Young Whan
dc.contributor.authorHong, Su Hyun
dc.contributor.authorPark, Cheol
dc.contributor.authorChoi, Yung Hyun
dc.date.accessioned2017-08-28T13:10:59Z
dc.date.available2017-08-28T13:10:59Z
dc.date.issued2017-03-14
dc.description.abstractSchisandrae Fructus, the fruit of Schisandra chinensis (Turcz.) Baill., is widely used in traditional medicine for the treatment of a number of chronic diseases. Although, Schisandrae Fructus was recently reported to attenuate the interleukin (IL)-1β-induced inflammatory response in chondrocytes in vitro, its protective and therapeutic potential against osteoarthritis (OA) in an animal model remains unclear. Therefore, we investigated the effects of the ethanol extract of Schisandrae Fructus (SF) on inflammatory responses and cartilage degradation in a monosodium iodoacetate (MIA)-induced OA rat model. Our results demonstrated that administration with SF had a tendency to attenuate MIA-induced damage of articular cartilage as determined by a histological grade of OA. SF significantly suppressed the production of pro-inflammatory cytokines such as interleukin (IL)-1β, IL-6, and tumor necrosis factor-α in MIA-induced OA rats. SF also effectively inhibited expression of inducible nitric oxide (NO) synthase and cyclooxygenase-2, thereby inhibiting the release of NO and prostaglandin E2. In addition, the elevated levels of matrix metalloproteinases-13 and two biomarkers for diagnosis and progression of OA, such as cartilage oligomeric matrix protein and C-telopeptide of type II collagen, were markedly ameliorated by SF administration. These findings indicate that SF could be a potential candidate for the treatment of OA.en
dc.identifier.doi10.17179/excli2017-119
dc.identifier.issn1611-2156
dc.identifier.urihttp://hdl.handle.net/2003/36076
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-18092
dc.language.isoen
dc.relation.ispartofseriesEXCLI Journal;Vol. 16 2017
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectSchisandrae Fructusen
dc.subjectOsteoarthritisen
dc.subjectMIAen
dc.subjectinflammatory responsesen
dc.subjectcartilage degradationen
dc.subject.ddc610
dc.titleSchisandrae Fructus ethanol extract ameliorates inflammatory responses and articular cartilage damage in monosodium iodoacetate-induced osteoarthritis in ratsen
dc.typeText
dc.type.publicationtypearticle
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1

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