Tumor mutation burden associated with miRNA-gene interaction outcome mediates the survival of patients with liver hepatocellular carcinoma
| dc.contributor.author | Yu, Qing-Jiang | |
| dc.contributor.author | Liang, Yi-Zhi | |
| dc.contributor.author | Mei, Xiao-Ping | |
| dc.contributor.author | Fang, Tai-Yong | |
| dc.date.accessioned | 2020-12-07T17:02:35Z | |
| dc.date.available | 2020-12-07T17:02:35Z | |
| dc.date.issued | 2020-06-22 | |
| dc.description.abstract | Tumor mutation burden (TMB) is associated with immunogenic responses and the survival of cancer patients. This study demonstrates how TMB levels impact the immune-related cells, genes, and miRNAs, and how miRNA/gene interactions respond to variations in the survival rate of patients with liver hepatocellular carcinoma (LIHC). LIHC patients were divided into two groups, either a low TMB (< median) or a high TMB (≥ median) group. We found that high TMB plays a positive role in immune-mediated infiltration, generating more CD4 T-cells and memory B cells. Among the 21 immune genes that altered significantly, only C9orf24 and CYP1A1 were expected to up-regulate in LIHC patients with high TMB. A total of 19 miRNAs, which regulate various functional pathways, were significantly altered in patients with LIHC. One of the miRNA/gene pair, hsa-miR-33a/ALDH1A3 was significantly associated with the survival rate of LIHC patients. Our results suggest that LIHC patients with high TMB can be treated more effectively with immunotherapy. | en |
| dc.identifier.citation | https://www.excli.de/index.php/excli/article/view/2171 | de |
| dc.identifier.issn | 1611-2156 | |
| dc.identifier.uri | http://hdl.handle.net/2003/39856 | |
| dc.identifier.uri | http://dx.doi.org/10.17877/DE290R-21747 | |
| dc.language.iso | en | |
| dc.publisher | IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund | de |
| dc.relation.ispartofseries | EXCLI Journal;Vol. 19. 2020, p. 861-871 | |
| dc.subject | Tumor mutation burden (TMB) | en |
| dc.subject | miRNA-gene interaction | en |
| dc.subject | Liver hepatocellular carcinoma (LIHC) | en |
| dc.subject | Prognosis | en |
| dc.subject.ddc | 610 | |
| dc.title | Tumor mutation burden associated with miRNA-gene interaction outcome mediates the survival of patients with liver hepatocellular carcinoma | en |
| dc.type | Text | |
| dc.type.publicationtype | article | |
| dcterms.accessRights | open access | |
| eldorado.dnb.zdberstkatid | 2132560-1 | |
| eldorado.secondarypublication | true |