Proteomic and bioinformatic discovery of biomarkers for diabetic nephropathy
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Date
2018-03-26
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Abstract
Diabetes is associated with numerous metabolic and vascular risk factors that contribute to a high rate of microvascular
and macro-vascular disorders leading to mortality and morbidity from diabetic complications. In this
case, the major cause of death in overall diabetic patients results from diabetic nephropathy (DN) or renal failure.
The risk factors and mechanisms that correspond to the development of DN are not fully understood and so far,
no specific and sufficient diagnostic biomarkers are currently available other than micro- or macroalbuminuria.
Therefore, this review describes current and novel protein biomarkers in the context of DN as well as probable
proteins biomarkers associated with pathological processes for the early stage of DN via proteomics data together
with bioinformatics. In addition, the mechanisms involved in early development of diabetic vascular disorders
and complications resulting from glucose induced oxidative stress will also be explored.
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Keywords
Diabetes, Diabetic nephropathy, Early biomarkers, Proteomics, Bioinformatics