Changes of serum omentin-1 levels and relationship between omentin-1 and insulin resistance in chronic hepatitis C patients
| dc.contributor.author | Nassif, Walaa Moustafa Hussein | |
| dc.contributor.author | Amin, Ashraf Ismail | |
| dc.contributor.author | Hassan, Zeinab Abdeltawab | |
| dc.contributor.author | Abdelaziz, Dalia Hussein Abdelhafiz | |
| dc.date.accessioned | 2014-03-12T13:50:42Z | |
| dc.date.available | 2014-03-12T13:50:42Z | |
| dc.date.issued | 2013-11-04 | |
| dc.description.abstract | Omentin-1 is a novel adipokine that has a pivotal role in modulating the insulin sensitivity, immunity and inflammation. The current study was conducted to evaluate the serum omentin-1 level in hepatitis C virus (HCV) infected patients, with or without type 2 diabetes, and to investigate its correlation with liver function parameters and insulin resistance. Methods: Eighty subjects were enrolled in this study divided into four groups: chronic HCV infected patients (n=20), chronic hepatitis C patients with concomitant type 2 diabetes (n=18), type 2 diabetic patients (n=22) and 20 healthy controls. Serum omentin-1 levels were assessed using enzyme-linked immunosorbent assay (ELISA). Fasting blood glucose, insulin levels, and liver parameters including aminotrans ferases (ALT and AST) were determined. Results: Serum omentin-1 levels were significantly elevated in HCV infected patients compared to all other groups. Omentin-1 levels were positively correlated with AST and ALT levels (r =0.43, p< 0.001; r =0.423, p<0.001, respectively). Additionally, a significant negative correlation was found between omentin-1 and both fasting insulin levels and homeostasis model assessment of insulin resistance (HOMA-IR) (r = -0.238, p< 0.05; r = -0.277, p<0.05, respectively). Furthermore, fasting blood glucose, HbA1c and HOMA-β were negatively correlated to serum omentin-1 levels however these correlations were not statistically significant. Conclusion: Serum omentin-1 level is elevated in HCV infected patients and is positively associated with liver enzymes AST and ALT. This suggested that omentin-1 may be implicated in the pathogenesis of hepatitis C and its metabolic complications. However its role needs to be elucidated by further studies. | en |
| dc.identifier.issn | 1611-2156 | |
| dc.identifier.uri | http://hdl.handle.net/2003/32969 | |
| dc.identifier.uri | http://dx.doi.org/10.17877/DE290R-7229 | |
| dc.language.iso | en | |
| dc.relation.ispartofseries | EXCLI Journal ; Vol. 12, 2013 | en |
| dc.subject | hepatitis C | en |
| dc.subject | insulin resistance | en |
| dc.subject | omentin-1 | en |
| dc.subject | type 2 diabetes | en |
| dc.subject.ddc | 610 | |
| dc.title | Changes of serum omentin-1 levels and relationship between omentin-1 and insulin resistance in chronic hepatitis C patients | en |
| dc.type | Text | |
| dc.type.publicationtype | article | |
| dcterms.accessRights | open access | |
| eldorado.dnb.zdberstkatid | 2132560-1 |