Transition metal-free cycloisomerization of propargylic amides to oxazoles in hexafluoroisopropanol (HFIP)

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dc.contributor.authorJankowski, Nicholas
dc.contributor.authorDietrich, Julian
dc.contributor.authorKrause, Norbert
dc.date.accessioned2024-01-22T14:56:58Z
dc.date.available2024-01-22T14:56:58Z
dc.date.issued2022-08-08
dc.description.abstractA transition metal-free method for the cycloisomerization of propargylic amides to oxazoles was developed. The reaction utilizes in situ generated hydrogen chloride in hexafluoroisopropanol (HFIP). With the aid of Design of Experiments optimization a wide range of substrates was transformed into the desired oxazoles. The method allows product formation without side reactions eliminating the need for extensive work-up and purification.en
dc.identifier.urihttp://hdl.handle.net/2003/42292
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-24128
dc.language.isoende
dc.relation.ispartofseriesAdvanced synthesis & catalysis;364(19)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/de
dc.subjectBrønsted acid catalysisen
dc.subjectCycloisomerizationen
dc.subjectDesign of Experimentsen
dc.subjectSolvent effectsen
dc.subjectTransition metal-free synthesisen
dc.subject.ddc540
dc.titleTransition metal-free cycloisomerization of propargylic amides to oxazoles in hexafluoroisopropanol (HFIP)en
dc.typeTextde
dc.type.publicationtypeResearchArticlede
dcterms.accessRightsopen access
eldorado.dnb.deposittruede
eldorado.secondarypublicationtruede
eldorado.secondarypublication.primarycitationN. Jankowski, J. Dietrich, N. Krause, Adv. Synth. Catal. 2022, 364, 3404.de
eldorado.secondarypublication.primaryidentifierhttps://doi.org/10.1002/adsc.202200559de

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Organische Chemie