Enzymatic hydrolysate from velvet antler suppresses adipogenesis in 3T3-L1 cells and attenuates obesity in high-fat diet-fed mice
| dc.contributor.author | Ding, Yuling | |
| dc.contributor.author | Wang, Yanmei | |
| dc.contributor.author | Jeon, Byong-Tae | |
| dc.contributor.author | Moon, Sang-Ho | |
| dc.contributor.author | Lee, Seung-Hong | |
| dc.date.accessioned | 2017-10-17T14:14:34Z | |
| dc.date.available | 2017-10-17T14:14:34Z | |
| dc.date.issued | 2017-03-22 | |
| dc.description.abstract | The purpose of the current study was to investigate the potential anti-obesity activity of an enzymatic hydrolysate of velvet antler in inhibiting adipogenesis in 3T3-L1 cells and in high-fat diet (HFD)-fed obese mice. The enzy- matic hydrolysate was prepared using the commercial food grade protease, Protamex. The velvet antler Protamex hydrolysate (VAPH) indicated profound inhibitory effects on adipogenesis dose-dependently by decreasing the accumulation of triglycerides and down-regulating expression levels of adipogenesis-related proteins C/EBPα, SREBP-1, and PPARγ. In a mouse model of HFD-induced obesity, oral administration of VAPH (100 and 300 mg/kg for 13 weeks) significantly reduced the body weight gain that had resulted from the HFD. VAPH treat- ment also lowered the serum glucose and triglyceride levels, while increasing the HDL-C level. Furthermore, the treatment greatly reduced hepatic lipid droplet accumulation as well as the size of adipocytes. Current findings H has profound anti-obesity effects and could be an effective candidate for preventing obesity and obesity-related chronic diseases. | en |
| dc.identifier.issn | 1611-2156 | |
| dc.identifier.uri | http://hdl.handle.net/2003/36120 | |
| dc.identifier.uri | http://dx.doi.org/10.17877/DE290R-18136 | |
| dc.language.iso | en | |
| dc.relation.ispartofseries | EXCLI Journal;Vol. 16 2017 | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | velvet antler | en |
| dc.subject | enzymatic hydrolysate | en |
| dc.subject | 3T3- L1 cells | en |
| dc.subject | high-fat diet | en |
| dc.subject | anti-obesity effect | en |
| dc.subject.ddc | 610 | |
| dc.title | Enzymatic hydrolysate from velvet antler suppresses adipogenesis in 3T3-L1 cells and attenuates obesity in high-fat diet-fed mice | en |
| dc.type | Text | |
| dc.type.publicationtype | article | |
| dcterms.accessRights | open access | |
| eldorado.dnb.zdberstkatid | 2132560-1 | |
| eldorado.secondarypublication | true |