The role of LIPG in regulating cholesterol homeostasis in cancer
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Date
2024
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Abstract
The endothelilal lipase or lipase G (LIPG) is expressed in cancer cells and high LIPG expression is shown to be associated with shorter metastasis free survival in untreated woman with node-negative breast cancer. LIPG is a cell surface associated lipase with multifaceted roles. It displays phospholipase A1 activity towards phosphatidylcholine in high-density lipoproteins (HDL), thereby releasing lysophosphatidylcholine (LPC) and free fatty acids, which can be used by the cells. In addition, LIPG has a non-enzymatic bridging function, enhancing the docking of lipoproteins to the cell surface. This could influence cholesterol exchange between cells and lipoproteins. Despite the important role of cholesterol tumor progression, the contribution of LIPG in tumor cholesterol homeostasis has not been studied so far. Thus, this study addresses the impact of LIPG on cholesterol metabolism in cancer cells.
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Cancer, Cholesterol, LIPG, SR-BI, Metastasis