Smoking, genetic polymorphisms of glutathione S-transferases and biological indices of inflammation and cellular adhesion in the STANISLAS study

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dc.contributor.authorBolt, Hermann M.de
dc.contributor.authorHabdous, Mohammedde
dc.contributor.authorHaddy, Nadiade
dc.contributor.authorHerbeth, Bernardde
dc.contributor.authorLambert, Danielde
dc.contributor.authorPonthieux, Annede
dc.contributor.authorSiest, GĂ©rardde
dc.contributor.authorThier, Ricardade
dc.contributor.authorVisvikis, Sophiede
dc.date.accessioned2008-06-17T13:46:21Z
dc.date.available2008-06-17T13:46:21Z
dc.date.issued2004-09-13de
dc.description.abstractA recent clinical study has focused on: 1- the interaction between genetic variants of glutathione S-transferases M1 and T1 (GSTM1 and GSTT1) and smoking on the risk of cardiovascular diseases, 2- the potential capacity of GSTM1 and T1 genotypes in modifying the effect of smoking on inflammation and endothelial function. In this study, we investigated whether carriage of these 2 polymorphisms altered the smoking impact on biological indices of inflammation and cellular adhesion. White blood cell count (WBC), albumin, C-reactive protein (CRP), interleukine-6 (IL-6), tumor necrosis factor-alpha (TNF-a), L-selectin, E-selectin, P-selectin and intracellular adhesion molecule-1 (ICAM-1) were measured in 189 non-smokers and 76 smokers (aged 20-55 years) genotyped for the GSTM1 and T1 polymorphisms. Accounting for age and sex, smokers lacking GSTM1 had a higher WBC count, CRP and ICAM-1 levels as compared to the other groups; interaction term between smoking and genotype being significant (p=0.05). Conversely, non-smokers lacking GSTM1 had a higher levels of TNF-a; the test for interaction being significant (p=0.05). No significant interaction was found between smoking and GSTT1 genotypes, considering the 9 biological indices. However, significantly lower levels of IL-6 were noticed for non-smokers with GSTT1-0 null allele (p=0.05). Our study confirms previous results showing that GSTM1 polymorphism could modulate the interrelationships between smoking and biological markers of inflammation and endothelial function.en
dc.identifier.issn1611-2156de
dc.identifier.urihttp://hdl.handle.net/2003/25637
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-8172
dc.language.isoende
dc.relation.ispartofseriesEXCLI Journal ; Vol. 3, 2004en
dc.subjectadhesionen
dc.subjectglutathione S-transferase polymorphismen
dc.subjectinflammationen
dc.subjectmoleculeen
dc.subjectsmokingen
dc.subject.ddc610
dc.titleSmoking, genetic polymorphisms of glutathione S-transferases and biological indices of inflammation and cellular adhesion in the STANISLAS studyen
dc.typeTextde
dc.type.publicationtypearticlede
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1

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