Dynamics and length distributions of microtubules with a multistep catastrophe mechanism

Simple item page
dc.contributor.authorSchwietert, Felix
dc.contributor.authorHeydenreich, Lina
dc.contributor.authorKierfeld, Jan
dc.date.accessioned2024-04-12T11:51:22Z
dc.date.available2024-04-12T11:51:22Z
dc.date.issued2023-01-23
dc.description.abstractRegarding the experimental observation that microtubule (MT) catastrophe can be described as a multistep process, we extend the Dogterom–Leibler model for dynamic instability in order to discuss the effect that such a multistep catastrophe mechanism has on the distribution of MT lengths in the two regimes of bounded and unbounded growth. We show that in the former case, the steady state length distribution is non-exponential and has a lighter tail if multiple steps are required to undergo a catastrophe. If rescue events are possible, we detect a maximum in the distribution, i.e. the MT has a most probable length greater than zero. In the regime of unbounded growth, the length distribution converges to a Gaussian distribution whose variance decreases with the number of catastrophe steps. We extend our work by applying the multistep catastrophe model to MTs that grow against an opposing force and to MTs that are confined between two rigid walls. We determine critical forces below which the MT is in the bounded regime, and show that the multistep characteristics of the length distribution are largely lost if the growth of an MT in the unbounded regime is restricted by a rigid wall. All results are verified by stochastic simulations.en
dc.identifier.urihttp://hdl.handle.net/2003/42435
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-24271
dc.language.isoende
dc.relation.ispartofseriesNew journal of physics;25(1)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/de
dc.subjectmicrotubuleen
dc.subjectdynamic instabilityen
dc.subjectcatastropheen
dc.subjectmultistepen
dc.subject.ddc530
dc.titleDynamics and length distributions of microtubules with a multistep catastrophe mechanismen
dc.typeTextde
dc.type.publicationtypeArticlede
dcterms.accessRightsopen access
eldorado.secondarypublicationtruede
eldorado.secondarypublication.primarycitationFelix Schwietert et al 2023 New J. Phys. 25 013017de
eldorado.secondarypublication.primaryidentifierhttps://doi.org/10.1088/1367-2630/acb07bde

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Schwietert_2023_New_J._Phys._25_013017.pdf
Size:
1.01 MB
Format:
Adobe Portable Document Format
Description:
DNB
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
4.85 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Theoretische Physik I