Exploiting in vitro potential and characterization of surface modified zinc oxide nanoparticles of Isodon rugosus extract
Loading...
Date
2018-07-16
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Little is known about biogenically synthesized Zinc oxide nanoparticles (ZnONPs) from Isodon rugosus. Synthesis
of metal oxide NPs from essential oil producing medicinal plants results in less harmful side effects to the
human population as compared to chemically synthesized NPs. In this article, we report biogenic synthesis of
ZnONPs from in vitro derived plantlets and thidiazuron (TDZ) induced callus culture of Isodon rugosus. Synthesized
NPs were characterized using UV-spectra, XRD, FTIR, SEM and EDX. Furthermore, the NPs were evaluated
for their potential cytotoxic (against HepG2 cell line) and antimicrobial (against drug resistant Staphylococcus
epidermidis, Bacillus subtilis, Klebsiella pneumoniae and Pseudomonas aeruginosa) activities. Pure crystalline
ZnONPs with hexagonal and triangular shapes were obtained as a result of callus extract (CE) and whole
plant extract (WPE), respectively. ZnONPs showed potent cytotoxic and antimicrobial potential. The antimicrobial
and cytotoxic activities of ZnONPs were found to be shape and surface bound phytochemicals dependent.
CE mediated hexagonal ZnONPs showed superior anti-cancer and antimicrobial activities as compared to WPE
mediated triangular shaped ZnONPs. It is concluded that biogenic ZnONPs have incredible potential as
theranostic agents and can be adopted as useful drug delivery system in next generation treatment strategies.
Description
Table of contents
Keywords
Nanotoxicity, ZnONP, pH, Surface adaptation, Characterization, Isodon rugosus