Immunoregulatory, proliferative and anti-oxidant effects of nanocurcuminoids on adipose-derived mesenchymal stem cells

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dc.contributor.authorYousefi, Forouzan
dc.contributor.authorLavi Arab, Fahimeh
dc.contributor.authorJaafari, Mahmoud Reza
dc.contributor.authorRastin, Maryam
dc.contributor.authorTabasi, Nafiseh
dc.contributor.authorHatamipour, Mahdi
dc.contributor.authorNikkhah, Karim
dc.contributor.authorMahmoudi, Mahmoud
dc.date.accessioned2020-02-12T11:38:45Z
dc.date.available2020-02-12T11:38:45Z
dc.date.issued2019-06-17
dc.description.abstractCurcuminoids are dietary complexes extracted from the seeds of Curcuma longa L. that contain curcumin, bisdemethoxycurcumin and desmethoxycurcumin. Curcuminoids are popular for their pleiotropic therapeutic functions, such as their anti-inflammatory and anti-oxidant effects. Nonetheless, their clinical use is associated with poor systemic bioavailability and insolubility. The nano-formulation of curcuminoids eliminates these shortcomings. In the present study, we explored immunoregulatory, proliferative and anti-oxidant effects of nanocurcuminoids on adipose-derived mesenchymal stem cells (AT-MSCs). Flow cytometry analysis and MTT assay were employed to explore the effects of nanocurcuminoids on the apoptosis and proliferation of adipose-derived MSCs (AT-MSCs). The anti-oxidant effect of nanocurcuminoids on AT-MSCs also was examined. The immune regulatory effect of nanocurcuminoids was evaluated by the flow cytometric measurement of the T regulatory (Treg) population. The expression of inflammatory and anti-inflammatory cytokines was quantified using real-time PCR. Our findings demonstrate that low concentrations of nanocurcuminoids are beneficial for MSC proliferation, protection of MSCs from apoptosis, reducing inflammatory cytokines and SOD activity. A high concentration of nanocurcuminoids increases the population of Tregs and elevates the expression of TGFβ and FOXP3 genes. The beneficial effects of nanocurcuminoids on AT-MSCs were mainly observed at low doses of nanocurcuminoids.en
dc.identifier.issn1611-2156
dc.identifier.urihttp://hdl.handle.net/2003/38564
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-20483
dc.language.isoen
dc.relation.ispartofseriesEXCLI Journal;Vol. 18 2019
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectImmunoregulatoryen
dc.subjectAntioxidanten
dc.subjectNanocurcuminoidsen
dc.subjectAdipose-derived mesenchymal stem cellsen
dc.subject.ddc610
dc.titleImmunoregulatory, proliferative and anti-oxidant effects of nanocurcuminoids on adipose-derived mesenchymal stem cellsen
dc.typeText
dc.type.publicationtypearticle
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1
eldorado.secondarypublicationtrue

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