Hesperidin, a plant flavonoid accelerated the cutaneous wound healing in streptozotocin-induced diabetic rats

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dc.contributor.authorLi, Wenbin
dc.contributor.authorKandhare, Amit D.
dc.contributor.authorMukherjee, Anwesha A.
dc.contributor.authorBodhankar, Subhash L.
dc.date.accessioned2018-08-22T11:50:11Z
dc.date.available2018-08-22T11:50:11Z
dc.date.issued2018-05-04
dc.description.abstractBackground: Delayed wound healing is a diverse, multifactorial, complex and inter-related complication of diabetes resulting in significant clinical morbidity. Hesperidin possesses potent antidiabetic and wound healing activity. Aim: To evaluate the potential of hesperidin against experimentally induced diabetes foot ulcers. Methods: Diabetes was induced experimentally by streptozotocin (STZ, 55 mg/kg, i.p.) in Sprague Dawley rats (180-220 g) and wounds were created on the dorsal surface of the hind paw of rats. Hesperidin (25, 50 and 100 mg/kg, p.o.) was administered for 21 days after wound stabilization. Various biochemical, molecular and histopathological parameters were evaluated in wound tissue. Results: STZ-induced decrease in body weight and increase in blood glucose, food, and water intake was significantly (p < 0.05) inhibited by hesperidin (50 and 100 mg/kg) treatment. It showed a significant increase (p < 0.05) in percent wound closure and serum insulin level. The STZ-induced decrease in SOD and GSH level, as well as elevated MDA and NO levels, were significantly (p < 0.05) attenuated by hesperidin (50 and 100 mg/kg) treatment. Intraperitoneal administration of STZ caused significant down-regulation in VEGF-c, Ang-1, Tie-2, TGF-β and Smad 2/3 mRNA expression in wound tissues whereas hesperidin (50 and 100 mg/kg) treatment showed significant up-regulation in these mRNA expressions. STZ-induced alteration in would architecture was also attenuated by hesperidin (50 and 100 mg/kg) treatment. Conclusion: Together, treatment with hesperidin accelerate angiogenesis and vasculogenesis via up-regulation of VEGF-c, Ang-1/Tie-2, TGF-β and Smad-2/3 mRNA expression to enhance wound healing in chronic diabetic foot ulcers.en
dc.identifier.issn1611-2156
dc.identifier.urihttp://hdl.handle.net/2003/37104
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-19100
dc.language.isoen
dc.relation.ispartofseriesEXCLI Journal;Vol. 17 2018
dc.relation.replaceshttp://hdl.handle.net/2003/37103
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectDiabetic foot ulceren
dc.subjectHesperidinen
dc.subjectVEGF-cen
dc.subjectAng-1en
dc.subjectTie-2en
dc.subjectTGF-βen
dc.subjectSmad 2/3en
dc.subject.ddc610
dc.titleHesperidin, a plant flavonoid accelerated the cutaneous wound healing in streptozotocin-induced diabetic ratsen
dc.title.alternativerole of TGF-ß/Smads and Ang-1/Tie-2 signaling pathwaysen
dc.typeText
dc.type.publicationtypearticle
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1
eldorado.secondarypublicationtrue

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