Wartungsarbeiten: Am 16.01.2025 von ca. 8:00 bis 11:00 Uhr steht Ihnen das System nicht zur Verfügung. Bitte stellen Sie sich entsprechend darauf ein.
 

Editorial 2020

Permanent URI for this collection

http://hdl.handle.net/2003/38448

News

Editors

  • J. G. Hengstler
    Leibniz Research Centre for Working Environment and Human Factors
    Ardeystr. 67
    D-44139 Dortmund
    Germany

Editorial Board

Address & Contact:

Susanne Lindemann
Managing editor/EXCLI Journal
Leibniz Research Centre for Working Environment and Human Factors
Ardeystraße 67
D-44139 Dortmund
Germany
Fon +49 231 1084 251

Browse

Recent Submissions

Now showing 1 - 4 of 4
  • Thumbnail Image
    Item
    Editor’s choice 2019
    (IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund, 2020-12-15) Ghallab, Ahmed
  • Thumbnail Image
    Item
    Editor’s choice 2018
    (IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund, 2020-12-22) Ghallab, Ahmed
  • Thumbnail Image
    Item
    Highlight report: New insights in liver physiology
    (IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund, 2020-08-31) Ezzat Ahmed, Ahmed
    One of the central functions of the liver is excretion of bile into the intestine. Currently, bile excretion is explained by the osmotic model, according to which bile acids are excreted by hepatocytes into the bile canaliculi and since bile acids are osmotically active they draw water into the canalicular lumen. Bile canaliculi are closed at the central side. Therefore, bile was postulated to flow to the open side into the ducts. However, bile flow in canaliculi has never been measured because of the small canalicular diameter which does not allow analysis of flux by conventional methods. Recently, methods have been developed that allow flow analysis in bile canaliculi and ducts. Interestingly, no measurable directed flow was observed in the canaliculi. Instead, small molecules in bile canaliculi reached the larger bile ducts by diffusion. Only there measurable flow sets in. The pathophysiological implications of this novel observation are discussed.
  • Thumbnail Image
    Item
    Current editorial challenges
    (2019-12-19) Hengstler, Jan G.
    Since its foundation in 2002, Experimental and Clinical Sciences (EXCLI Journal) published more than 760 original articles and reviews, particularly in the field of cancer research (Abbastabar et al., 2018; Nojadeh et al., 2018; Karimian et al., 2018), cell biology (Li et al., 2017; Niknami et al., 2017; Ahmadi et al., 2017), toxicology (Randjelovic et al., 2017; Hassani et al., 2018; Nakhaee and Mehrpour, 2018), neurosciences (Farajdokht et al., 2017; Ebrahimi et al., 2017), drug discovery (Li et al., 2018; Khedher et al., 2017) and immunology (Fahimi et al., 2018; Sarvari et al., 2018). However, the editors are keen to keep a broad view of science and technology and also welcome manuscripts from other fields of life sciences and interdisciplinary studies. Our main criterion during the review process is the scientific quality of the study. Editors and reviewers focus particularly on whether the methods are sufficiently described, results are presented in a transparent way, have been sufficiently reproduced in independent experiments and justify the main conclusions. If this is the case, also confirmatory studies or studies reporting negative results may be published. Each manuscript should include a statement on the aim of the study and convincingly explain why the experiments are relevant. While a high degree of novelty is welcome, it is not our most important criterion in selecting manuscripts for publication.