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Review Articles

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    The necessity of extraction of ligand binding data from literature
    (2005-10-07) Marashi, Sayed-Amir
    After identification and validation of targets in a drug development process, some independent lead compounds should be selected and optimized for their activities. Then, safety assessments and clinical trials decide whether the drug is proper to enter the market. Different stages of this process (and especially the identification of lead compounds) are extremely expensive and time-consuming. Rational drug development methods try to reduce the costs by optimizing the pace of drug discovery and reducing the number of products abandoned during development. For decades, many investigators have studied the ligand-protein interactions, but very few structured databases are devoted to such information. Herein, development of such databases is proposed, since it is obvious that our prior knowledge about the chemico-biological interactions can help us choosing appropriate lead compounds without further experimental and computational investigations, which are usually based on searching in gigantic combinatorial databases of chemical compounds.
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    Canavan disease
    (2005-09-30) Surendran, Sankar
    Canavan disease (CD) is an autosomal recessive disorder, characterized by spongiform degeneration of the white matter of the brain. Aspartoacylase (ASPA) hydrolyses N-acetylaspartic acid to aspartate and acetate. Mutation of the gene results in enzyme deficiency to result CD. The clinical features seen in the disease are head lag, macrocephaly, hypotonia and mental retardation. More than forty five mutations have been identified in the ASPA gene. Pathophysiological abnormalities seen in CD is likely due to abnormal metabolic levels of NAA, aspartate, acetate, aspartate aminotransferase, glutamate, glutamate dehydrogenase, g-aminobutyric acid, and ketoglutarate dehydrogenase complex. These pathways are useful to understand possible therapeutical targets and pharmacological manipulations in CD.