Rational design of novel coumarins See

Coumarins are well-known for their antioxidant effect and aromatic property, thus, they are one of ingredients commonly added in cosmetics and personal care products. Quantitative structure-activity relationships (QSAR) modeling is an in silico method widely used to facilitate rational design and structural optimization of novel drugs. Herein, QSAR modeling was used to elucidate key properties governing antioxidant activity of a series of the reported coumarin-based antioxidant agents (1-28)....

In-utero exposure to opioid increases the risk of congenital heart defects See

Mental disorder or conscious disturbance in epidermal growth factor receptor-tyrosine kinase inhibitor treatment of advanced lung adenocarcinoma See

Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are currently recommended by international guidelines as first-line treatment in patients with advanced EGFR-mutant non-small-cell lung cancer. With the availability of drugs, more and more patients choose EGFR-TKI treatment. However, pharmaceutical drugs used in clinical practice have side effects, such as diarrhea, paronychia, and hepatotoxicity. Mental or conscious disturbance has never been reported before. In our cli...

PPARG as therapeutic target for antifibrotic therapy See

Association of biofilm formation with multi drug resistance in clinical isolates of Pseudomonas aeruginosa See

Pseudomonas aeruginosa is considered as foremost cause of hospital acquired infections due to its innate and plasmid mediated resistance to multiple antibiotics making it a multi drug resistant (MDR) pathogen. Biofilm formation is a pathogenic mechanism harbored by this pathogen which further elevates its resistance to antibiotics and host defense system. The aim of the present study was to evaluate the biofilm forming potential and distribution of pslA gene in multi drug resistant Pseudomona...

Sociotechnical perspectives on digitalisation and Industry 4.0 See

The sociotechnical systems approach and theory (STS) helps to deal with today's rapid digital transformations in designing best suitable work, organisations and jobs. Not surprisingly, related approaches based on STS assumptions, such as modern sociotechnical thinking (MST) and workplace innovation (WPI) theory, are rapidly developing in Europe. Yet, research and (theoretical) analyses that place STS in today's digital industry challenges and WPI are sparse. The basics of sociotechnical conce...

A new player for tackling inequalities? See

The Maker Movement has raised great expectations towards its potential for tackling social inequalities by mediating technology-related skills to everybody. Are maker spaces new players for social inclusion in digital societies? How can this potential impact be framed? While scientific discourse has so far identified broad value and impact dimensions of the Maker Movement, this article adds empirical insight into the potential for tackling social inequalities. The study is based on 39 intervi...

Soziale Verantwortung – ein Aspekt für Lehrformate der tertiären Bildung? See

This thesis investigates university social responsibility as mediated content of the Projektstudium courses of the bachelor study programme rehabilitation pedagogy of TU Dortmund University as well as Service Learning projects of the University Duisburg- Essen. In the course of societal change, tasks of educational institutions and their teaching concepts also change. In order to take responsibility for society and to educate responsibly acting citizens, university social responsibility...

A new innovation paradigm: combining technological and social innovation See

A new innovation paradigm is needed to answer the societal, economic and environmental challenges the world and companies are facing. The EU funded Horizon 2020 SPIRE Project “Coordinating Optimisation of Complex Industrial Processes” (COCOP) is combining technological and social innovation within a steel company pilot case (Sidenor). The project aims at reducing raw materials consumption (and energy and emissions reduction as well) by plant-wide optimisation of production processes based on ...

Redox status, DNA and HSA binding study of naturally occurring naphthoquinone derivatives See

In the present work we modified the procedure for isolation of naphthoquinones α-methylbutyrylshikon (1), acetylshikonin (2) and β-hydroxyisovalerylshikonin (3) from Onosma visianii Clem. We also investigated possible mechanisms of 1, 2 and 3 as antitumor agents. Accordingly, we estimated concentrations of superoxide anion radical (O2.-), nitrite (NO2 -) and glutathione in HCT-116 and MDA-MB-231 cell lines. Compounds 1 and 3 expressed significant prooxidative activity, while all tested compou...

The in vivo genotoxicity of isotretinoin assessed by comet assay See

Concomitant inflammation/metabolism transcriptional regulatory networks in liver disease See

Highlight Report See

A recent overview on sulforaphane as a dietary epigenetic modulator See

Concurrent chronic myeloid leukemia and CALR-mutated myeloproliferative neoplasm See

The survival rate of hepatocellular carcinoma in Asian countries See

Hepatocellular carcinoma or Liver cancer (LC) is the sixth most common cancer and the fourth cause of death worldwide in 2018. There has not been a comprehensive study on the survival rate of patients with LC in Asia yet. Therefore, the present study was conducted to evaluate the survival rate of patients with LC in Asian countries. The methodology of the present study is based on the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) statement. The researchers search...

Safety evaluation of FM101, an A3 adenosine receptor modulator, in rat, for developing as therapeutics of glaucoma and hepatitis See

Adenosine is a critical regulator of inflammation and fibrosis, it affects endogenous cell signaling via binding to the A3 adenosine receptor. FM101 is a potent, highly selective A3 adenosine receptor modulator that has been developed as a treatment for glaucoma and hepatitis. We determined that FM101 is a biased ligand with functional activities both as a G protein agonist and a β-arrestin antagonist. The safety of FM101 was evaluated by administering an acute dose in rats, the results indic...

CRISPR/Cas9-mediated knockout of MLL5 enhances apoptotic effect of cisplatin in HeLa cells in vitro See

Mixed lineage leukemia 5 (MLL5) transactivates the expression of E6 and E7 oncogenes in cervical cancer cells. In this study, we utilized ‎CRISPR/Cas9 system with the aim to target HPV-E6 and MLL5 to enhance apoptosis efficiency in HPV-18 positive HeLa cells and to improve chemotherapeutic efficacy of Cisplatin as the most common anticancer drug, used for cervical cancer. ‎sgRNAs against MLL5 and E6 were designed and cloned into PX458 plasmid vector. ‎Real-time ‎PCR was used to determine knoc...

Current editorial challenges See

Since its foundation in 2002, Experimental and Clinical Sciences (EXCLI Journal) published more than 760 original articles and reviews, particularly in the field of cancer research (Abbastabar et al., 2018; Nojadeh et al., 2018; Karimian et al., 2018), cell biology (Li et al., 2017; Niknami et al., 2017; Ahmadi et al., 2017), toxicology (Randjelovic et al., 2017; Hassani et al., 2018; Nakhaee and Mehrpour, 2018), neurosciences (Farajdokht et al., 2017; Ebrahimi et al., 2017), drug discovery (...