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dc.contributor.authorNeumann, Heinz-
dc.contributor.authorNeumann-Staubitz, Petra-
dc.contributor.authorWitte, Anna-
dc.contributor.authorSummerer, Daniel-
dc.date.accessioned2022-07-15T09:35:28Z-
dc.date.available2022-07-15T09:35:28Z-
dc.date.issued2018-02-22-
dc.identifier.urihttp://hdl.handle.net/2003/40994-
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-22843-
dc.description.abstractThe genetic incorporation of unnatural amino acids (UAAs) into proteins by amber suppression technology provides unique avenues to study protein structure, function and interactions both in vitro and in living cells and organisms. This approach has been particularly useful for studying mechanisms of epigenetic chromatin regulation, since these extensively involve dynamic changes in structure, complex formation and posttranslational modifications that are difficult to access by traditional approaches. Here, we review recent achievements in this field, emphasizing UAAs that help to unravel protein-protein interactions in cells by photo-crosslinking or that allow the biosynthesis of proteins with defined posttranslational modifications for studying their function and turnover in vitro and in cells.de
dc.language.isoende
dc.subjectGenetic Code Expansionde
dc.subjectUnnatural Amino Acidsde
dc.subjectUV-crosslinkingde
dc.subjectPost-translational modificationsde
dc.subjectBioorthogonal Chemistryde
dc.subject.ddc570-
dc.subject.ddc540-
dc.titleEpigenetic chromatin modification by amber suppression technologyde
dc.typeTextde
dc.type.publicationtypearticlede
dcterms.accessRightsopen access-
eldorado.openaire.projectidentifierinfo:eu-repo/grantAgreement/EC/H2020/723863/EU/Programmable Readers, Writers, and Erasers of the Epigenetic Cytosine Code/EPICODEde
eldorado.secondarypublicationtruede
eldorado.secondarypublication.primaryidentifierhttps://doi.org/10.1016/j.cbpa.2018.01.017de
eldorado.secondarypublication.primarycitationCurrent opinion in chemical biology. Volume 45, August 2018, Pages 1-9de
Appears in Collections:Lehrstuhl für Chemische Biologie der Nukleinsäuren

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