Strukturbasierte Entwicklung und Evaluierung von Sondenmolekülen zur allosterischen Regulation von Isoformen der Proteinkinase Akt See

Biochemische und strukturbiologische Evaluierung von MKK7-Ligand Wechselwirkungen See

Design, synthesis and biological evaluation of a pseudo natural product compound collection See

Novel concepts and methodologies in pseudo natural product chemistry See

FGF4 drives intermittent oscillations of ERK activity in mouse embryonic stem cells See

Designer receptors for nucleotide-resolution analysis of genomic 5-Methylcytosine by cellular imaging See

TEAD-YAP interaction inhibitors and MDM2 binders from DNA-encoded indole-focused Ugi-peptidomimetics See

A biochemical pacemaker system for robust actin growth See

Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations See

Engineered TALE repeats for enhanced imaging-based analysisof cellular 5-Methylcytosine See

Struktur-basiertes Design, Synthese und pharmakokinetische Charakterisierung von kovalenten Inhibitoren zur Adressierung von Krebs-relevanten Proteinkinasen See

Pseudo-natural products via Pictet-Spengler reaction and dearomatization See

Morphological profiling of small molecules for mode-of-action studies using the Cell Painting Assay See

Role of histone modifications in the recruitment of remodeling complex RSC and lysine deacetylase Hst2 to chromatin See

Structural investigations on cholesterol binding membrane proteins SREBP cleavage-activating protein (Scap) and Patched1 by cryo-EM See

Sequence-specific DNA binders for nucleotide resolution analysis genomic 5-methylcytosine by cell imaging See

Kristallisation und strukturbiologische Charakterisierung klinisch-relevanter Mutationsvarianten der Rezeptor-Tyrosinkinasen EGFR und Her2 See

A role of glycerophosphodiesterase EDI3 in glycogen metabolism See

Strukturbiologische Untersuchung und zelluläre Charakterisierung kovalent-allosterischer Akt-Inhibitoren See