Authors: Kriegler, Simon
Jaworek, Michel W.
Oliva, Rosario
Winter, Roland
Title: High pressure treatment promotes the deteriorating effect of cationic antimicrobial peptides on bacterial membranes
Language (ISO): en
Abstract: The helical structure that cationic antimicrobial peptides (cAMPs) adopt upon interaction with membranes is key to their activity. We show that a high hydrostatic pressure not only increases the propensity of cAMPs to adopt a helical conformation in the presence of bacterial lipid bilayer membranes, but also in bulk solution, and the effect on bacterial membranes persists even up to 10 kbar. Therefore, high-pressure treatment could boost cAMP activity in high-pressure food processing to extend the shelf-life of food.
Issue Date: 2023-03-29
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Appears in Collections:Physikalische Chemie

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