Authors: | Kriegler, Simon Jaworek, Michel W. Oliva, Rosario Winter, Roland |
Title: | High pressure treatment promotes the deteriorating effect of cationic antimicrobial peptides on bacterial membranes |
Language (ISO): | en |
Abstract: | The helical structure that cationic antimicrobial peptides (cAMPs) adopt upon interaction with membranes is key to their activity. We show that a high hydrostatic pressure not only increases the propensity of cAMPs to adopt a helical conformation in the presence of bacterial lipid bilayer membranes, but also in bulk solution, and the effect on bacterial membranes persists even up to 10 kbar. Therefore, high-pressure treatment could boost cAMP activity in high-pressure food processing to extend the shelf-life of food. |
URI: | http://hdl.handle.net/2003/42587 http://dx.doi.org/10.17877/DE290R-24422 |
Issue Date: | 2023-03-29 |
Rights link: | https://creativecommons.org/licenses/by/3.0/ |
Appears in Collections: | Physikalische Chemie |
Files in This Item:
File | Description | Size | Format | |
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d3cp00560g.pdf | DNB | 960.51 kB | Adobe PDF | View/Open |
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