Anti-oncogenic perspectives of spices/herbs

dc.contributor.authorButt, Masood Sadiq
dc.contributor.authorNaz, Ambreen
dc.contributor.authorSultan, Muhammad Tauseef
dc.contributor.authorQayyum, Mir Muhammad Nasir
dc.date.accessioned2014-03-05T16:55:41Z
dc.date.available2014-03-05T16:55:41Z
dc.date.issued2013-12-17
dc.description.abstractContemporary nutrition regime has focused the attention of the researchers on phytochemicals enriched spices to mitigate various oncological threats. Numerous chemopreventive strategies against malignancy have been developed considering the anticancer perspectives of allied nutraceutical constituents. Current evidences have proven an inverse association of spices with that of oncological incidences. The high antioxidant activity of spices derived bioactives triggers the free radicals scavenging ability at cellular level thereby alleviating various metabolic syndromes. Promising compounds including curcumin and curcuminoids (turmeric), limonene (cardamom), allicin, allyl isothiocyanate (garlic), cinnamic aldehyde, 2-hydroxycinnamaldehyde and eugenol (cinnamon), gingerol, zingiberone, zingiberene (ginger), dipropyle disulfides and quercetin (onion), piperidine piperine, limonene, α- and β-pinene (black pepper), crocetin, crocin and safranal (saffron) have been identified as chemopreventing agents against various malignancies. Chemopreventive properties of spices are mediated by functional bioactive ingredients that arrest the activity of cytochrome P450 and isozymes CYP 1A1, cyclooxygenase-2, reducing activator of transcription-3 (STAT-3) and signal transducer. They are closely associated with tumorigenesis activated by interleukin-6 (IL-6) receptors and epidermal growth factor (EGF) relate to an array of tumors. The bioactive constituents altering the expression of protein involved in cell cycle, activating caspases killer and suppressing Kappa-B activation. Alongside, they also restrain causative agents of cell structure damage as in lipid and protein membrane system and DNA that shifting healthy body towards cancerous state. Spices phytochemicals have established as carcinogenesis blockers by modulating cell proliferation pathways transformation, inflammation, metastasis etc. Furthermore, spices as functional ingredients may act as immune boosters and diminish inflammatory disorders. The current review is inevitably an affirmative approach in the development of novel guidelines against cancer by using dietary species to maintain good health.en
dc.identifier.issn1611-2156
dc.identifier.urihttp://hdl.handle.net/2003/32919
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-7360
dc.language.isoende
dc.relation.ispartofseriesEXCLI Journal ; Vol. 12, 2013en
dc.subjectmalignancyen
dc.subjectallicinen
dc.subjectcinnamic aldehydeen
dc.subjectgingerolen
dc.subjectdipropyle disulfidesen
dc.subjectpiperidine piperineen
dc.subject.ddc610
dc.titleAnti-oncogenic perspectives of spices/herbsen
dc.title.alternativea comprehensive reviewen
dc.typeTextde
dc.type.publicationtypearticlede
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1

Files

Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Butt_17122013_proof.pdf
Size:
358.14 KB
Format:
Adobe Portable Document Format
Description:
DNB
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.85 KB
Format:
Item-specific license agreed upon to submission
Description:

Collections