Letters to the Editor 2020

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http://hdl.handle.net/2003/38449

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  • J. G. Hengstler
    Leibniz Research Centre for Working Environment and Human Factors
    Ardeystr. 67
    D-44139 Dortmund
    Germany

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Susanne Lindemann
Managing editor/EXCLI Journal
Leibniz Research Centre for Working Environment and Human Factors
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D-44139 Dortmund
Germany
Fon +49 231 1084 251

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Recent Submissions

Now showing 1 - 20 of 42
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    Examination of predictable factors of perioperative respiratory complications by preoperative forced oscillation technique parameters
    (IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund, 2020-12-21) Igarashi, Akira; Inoue, Sumito; Shibata, Yoko; Nunomiya, Keiko; Ota, Takahito; Ishibashi, Yu; Murano, Hiroaki; Furuyama, Kodai; Yang, Sujeong; Machida, Hiroyoshi; Nakano, Hiroshi; Sato, Kento; Sato, Masamichi; Nemoto, Takako; Nishiwaki, Michiko; Yamauchi, Keiko; Suzuki, Jun; Sadahiro, Mitsuaki; Watanabe, Masafumi
    In this study, we investigated whether pulmonary function tests such as forced oscillation technique parameters could predict perioperative respiratory complications. In the results of our study, perioperative respiratory complications cannot be predicted using the results of preoperative pulmonary function tests and forced oscillation technique parameters. Patients who are judged by comprehensive preoperative judgment to be suitable for general anesthesia may not need to consider the risk of perioperative complications using pulmonary function test.
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    Long time blood-transfusion trend in a European general hospital
    (IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund, 2020-06-19) Enko, Dietmar; Herrmann, Markus; Baranyi, Andreas; Schnedl, Wolfgang J.; Halwachs-Baumann, Gabriele
    Reports about long-time transfusion trends in Austrian hospitals are rare. In our hospital, we implemented an algorithm of preoperative anemia management as part of a patient blood management (PBM) program in October 2011. Anemic individuals with elective surgery underwent an adequate preoperative anemia classification and treatment with erythropoietin and intravenous iron. The aim of this study was to assess red blood cell (RBC), platelet and plasma transfusions before and after implementation of an anemia management program in a general hospital in Austria. This retrospective study evaluated a 12-year trend (2006 – 2017) of RBC, platelet and plasma transfusions in an Austrian general hospital comprising a 6-year period before (2006 – 2011) and a 6-year period after (2012 – 2017) the implementation of an algorithm-guided anemia management. From overall 49,142 transfused RBC units between 2006 - 2017, 22,745 units were transfused in the post-implementation period compared to 26,397 units before PBM initiation (-13.8 %). The plasma unit use decreased also distinctly (787 vs. 1065 units, - 26.1 %) in the period after PBM implementation, whereas a slight decrease of platelet concentration use (807 vs. 843 units, - 4.3 %) was observed, only. This study demonstrates a 12-year pattern of blood use in an Austrian hospital with a distinct decreasing trend of transfused RBC and plasma units during this period. The implementation of PBM activities decreased the need of blood utilization at our institution. Further initiatives are needed to continue this trend in the next years.
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    The multifactorial resistance of Pseudomonas aeruginosa
    (IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund, 2020-06-17) Meliani, Amina
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    Can post-splenectomy thrombocytosis mask essential thrombocythaemia?
    (IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund, 2020-06-08) Langabeer, Stephen E.
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    Nut consumption and risk of diabetes mellitus in overweight/obese individuals
    (IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund, 2020-05-29) Eslami, Omid; Shidfar, Farzad
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    Genotoxicity effect of methyl-tertiary butyl ether on rat lymphocytes using comet assay
    (IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund, 2020-05-25) Alishahi, Shima; Zendeh-Boodi, Zahra; Saadat, Mostafa
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    COVID-19
    (IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund, 2020-06-15) Atolani, Olubunmi; Baker, Mariam Temitope; Adeyemi, Oluyomi Stephen; Olanrewaju, Ismaeel Ridwan; Hamid, Abdulmumeen A.; Ameen, Oluduowo M.; Oguntoye, Stephen O.; Usman, Lamidi A.
    The anxiety and trauma associated with the tragic coronavirus disease pandemic coded, COVID-19 led many to indulge in various unorthodox preventive measures such as the extensive indiscriminate use of alcohol-based hand sanitizers (ABHS), abuse, misuse, overdose of prescription drugs like chloroquine, hydroxychloroquine and chloroquine phosphate globally. While some preventive measures are recommended and adopted, such as national lockdown, self-isolation, quarantine, stay-at-home model, avoidance of large gathering, social distancing, wearing of face-masks and hand gloves, periodic hand washing particularly with liquid soaps/detergents under running tap water, avoidance of touching the face among others, the use of ABHS has been more prominent. ABHS contains on average 60-70 % by weight of one or more alcohols. During the 2019/2020 COVID-19 pandemic, the use of ABHS was more renowned to the extent that some individuals recommended the application on the hands every 30 minutes for a period of at least 20 seconds while outside the home. Though, the periodic application of the hand sanitizers seems like an effective on-the-go solution to preventing the spread of the virus, many other associated hazards call for caution. Besides transdermal absorption leading to mortality and morbidity of varying degree; alcohol-alcohol adulteration, deliberate and unintentional ingestion of ABHS may result in respiratory depression, irreversible blindness, intoxication, cirrhosis, acidosis, headache, central nervous system depression, seizure, hypoglycemia, coma, or even death in some cases. The non-ABHS are equally not absolutely safe as many of them contain active agents that are allegedly carcinogenic, toxic, inducing microbial resistance and endocrine disruption. Considered together, this implies that while some may not die from contracting the disease, the preventive measures taken could lead to death or other forms of morbidity thereby revealing that there is indeed, death in preventive measures when done without cautionary measures. This study seeks to highlight some associated risks in the use of ABHS and non-ABHS, whilst advocating the use of safer or ‘greener’ alternative procedure for use as preventive measures particularly during the COVID-19 pandemic.
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    Current biological and pharmacological updates on wogonin
    (IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund, 2020-05-13) Rawat, Sarita; Gupta, Gaurav; Pathak, Sachchidanand; Singh, Santosh Kumar; Singh, Himmat; Mishra, Anurag; Gilhotra, Ritu; Aljabali, Alaa A. A.; Dureja, Harish; Tambuwala, Murtaza M.; Chellappan, Dinesh K.; Dua, Kamal
    Wogonin (5, 7-Dihydroxy-8-methoxyflavone) is a traditional naturally occurring flavonoid derived from the root extract of Chinese medicine, named Scutellaria baicalensis Georgi. Wogonin contains various biological properties which include allergic diseases, anti-cancertherapy and anti-inflammatory activities. Wogonin also shows the effects of removing toxins and cleansing heat. Wogonin glycosides are known as wogonosides. Oroxindin, a wogonin glucuronide isolated from Oroxylum indicum, is one of the example of wogonoside. It is also used in Japanese herbal supplement named Sho-Saiko-To, as an important active ingredient. One of the major active constituents of wogonin, Scutellaria baicalensis, shows potent anticancer activities both in vivo and in vitro studies. The anticancer therapeutic activity of wogonin has been shown by regulation of different cell signaling pathways , which includes protein kinase B pathway (serine-threonine kinase) and AMP-activated protein kinase pathways. Wogonin also shows positive therapeutic anticancer effects in breast cancer by inhibiting the 5‑LO/BLT2/ERK/IL‑8/MMP‑9 signaling cascade and established a major pharmacological anticancer activity.
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    Recent insights into the biological functions of apigenin
    (IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund, 2020-07-06) Kim, Jae Kwang; Park, Sang Un
    Apigenin (4′,5,7-trihydroxyflavone) belongs to the group of flavonoids positioned on the backbone of 2-phenylchromen-4-one (2-phenyl-1-benzopyran-4-one) and is most extensively allocated in herbs, vegetables, and fruits. Biosynthetically, apigenin is obtained from the phenylpropanoid pathway and also from the flavone synthesis pathway. The pathway of phenylpropanoid begins from the aromatic amino acids L-phenylalanine or L-tyrosine, both products of the shikimate pathway. In several recent studies, it has been shown that apigenin has a number of valuable bioactive functions, including antibacterial, antiviral, antiproliferative, anti-inflammatory, antioxidant, antiangiogenic, and anticancer activities. From the results of several in vivo and in vitro studies and clinical trials, apigenin has been shown to be an effective curative treatment for rheumatoid arthritis, autoimmune disorders, Parkinson’s disease, Alzheimer’s disease, and several types of cancers. Here, we summarize the key findings of the biological and pharmacological actions of apigenin.
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    Hepatotoxicity of anesthetic gases
    (IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund, 2020-07-27) Albrecht, Wiebke
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    The link between long-term nut consumption and health outcomes
    (IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund, 2020-08-03) Eslami, Omid; Shidfar, Farzad
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    Recent pharmacological advances on genistein in clinical trials
    (IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund, 2020-08-05) Mathew, Shimy; Vazhappilly, Cijo George
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    Anticancer activity of luteolin glycosides
    (IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund, 2020-08-14) Ghallab, Ahmed
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    Kupffer cells in hepatotoxicity
    (IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund, 2020-08-14) Hassan, Reham
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    Do artificial sweeteners increase the risk of non-alcoholic fatty liver disease (NAFLD)?
    (IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund, 2020-08-14) Abbas, Tahany; Murad, Walaa
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    Vitamin D supplementation in COVID-19
    (IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund, 2020-08-17) Mansour, Asieh; Mohajeri-Tehrani, Mohammad Reza; Sajjadi-Jazi, Sayed Mahmoud
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    Rethinking “Exercise is Medicine”
    (IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund, 2020-08-18) Li, Shunchang; Laher, Ismail
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    Which concentrations are optimal for in vitro testing?
    (IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund, 2020-08-18) Albrecht, Wiebke
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    Reproductive toxicity of boron
    (IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund, 2020-08-19) Seidel, Florian
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    Mitigation of metabolic dyshomeostasis by glucocorticoid-receptor antagonism
    (IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund, 2020-09-09) Madhavan, Aishwariya; Murali, Kusuma; Raghavendra, Vaishnavi; Joshi, Apurva Kumar Ramesh